Pisa’s Galileo Galilei airport (www.pisa-airport.com) is the most convenient regional gateway, but Florence and Rome Fiumicino are also options. If you're a high-flier with your own jet, there is also a small airport in Siena (www.siena-airport.it) or in Perugia.
The main station in Florence is behind Piazza Santa Maria Novella; Florence acts as a hub for services to other Tuscan cities, including Siena and Pisa (www.trenitalia.com). Arezzo has a train station and direct fast trains stop here from Naples, Rome, Milan and Florence. Grosseto is on the main Rome-Genoa line and has frequent express services.
From Rome: follow signs to the autostrada A1, direction Firenze. It is about 180km from the tollbooth and will take two hours. Follow signs for Arezzo at 8km you will see a Tam Oil petrol station on your right and about 500m afterward a small blue sign for a left-hand turning to Pozzo – take this turning. Continue along this road for around 1.5 km passing by a small yellow church, on the left and then driving up a short incline at the top of which there is a turning to the left signed Via Cunicchio and Villa Fontelunga. The villa is 100m on the left-hand side: park under the pine trees. From Milan: Follow signs for autostrada A1 direction Bologna-Firenze. Continue after Firenze along the A1 towards Roma. Take the exit Monte san Savino about an hour from Firenze. After leaving the autostrada turn right and follow the road for around 2km until you see a right-hand turning to Marciano della Chiana – take this. At T-junction, turn left and continue for 300m and then take the right-hand turning for Pozzo della Chiana. From Florence: Initially follow directions for Prato. After three minutes, you’ll see signs for the A1. Join the autostrada in the direction of Roma. Take the exit Monte San Savino about an hour from Firenze. After leaving the autostrada, follow directions as for Milan. Directions from Pisa: Leave airport from the exit adjacent to the car rental parking depot and turn right in the direction signposted Firenze. Follow this dual carriageway all the way to Firenze. You will eventually, just outside Firenze, come to a signpost for the Autostrada A1 and Roma. Take this turning. Follow the exit off the road and round a bend to the right, you will come to a junction with a toll for the autostrada ahead; go in the direction of Roma, turning off, after one hour at the Monte san Savino exit. Then following the directions as for Milan. Directions from Perugia: Leave airport following signs to Perugia; after several turnings you arrive at a dual carriageway. Enter this and stay on it for a few kilometres – when you see a green sign for the A1 Florence take this exit (do not follow signs for the A1 Roma). Stay on this for around 30mins until Foiano exit. At the first set of traffic lights you come to turn right, signed Arezzo, follow this through another set of traffic lights and shortly afterwards turn right at a small roundabout. Stay on this road for about 3 km until Tam Oil petrol station (see above).